This is one of the first studies to examine the effect of amphetamines and related compounds on bone.
by Miriam E Tucker, medscape.com, 4 April 2016
BOSTON — Use of stimulant medications for treating attention-deficit/hyperactivity disorder (ADHD) in children appears to be associated with bone loss, new research shows.
The analysis of data from the 2005–2010 National Health and Nutrition Examination Survey (NHANES) were presented here at ENDO 2016 by Alexis Jamie Feuer, MD, assistant professor of pediatrics and a pediatric endocrinologist at Weill Cornell School of Medicine, New York, New York.
The study population included a total of 6489 NHANES participants aged 8 to 20 years, of whom 159 were receiving stimulants (primarily amphetamines or amphetamine analogs) for ADHD. After adjustment for confounders, those using the medications had a total 3.9% lower bone density at the lumbar spine and 3.7% lower bone density at the femoral neck compared with nonusers.
"These findings indicate that bone health may be a serious concern for kids and teens using stimulants. We know that failure to attain appropriate bone density by young adulthood puts an individual at increased lifetime risk of fractures and osteoporosis," Dr Feuer said during a press briefing.