“So far, genomic instability has been observed in cells in culture and in nonhuman organisms ranging from worms to rats. Understanding the nature of genomic instability has not proved possible within the conventional framework of biology, namely genetics. What is presented here is a major reformulation of the way biology works… The concepts used are more soundly based in physics than those used in conventional biology and the hypothesis has considerable explanatory power. It is therefore reasonable to try to formulate the long-term consequences of genomic instability. These are, over several generations, a progressive decline in the healthiness and well-being of affected individuals, including the bringing forward of diseases normally of late-onset and the occurrence of malformations. It may be 10 generations (300 years) before the full impact of genomic instability induced today is absolutely clear."
Genes without prominence: a reappraisal of the foundations of biologyArto Annila, Keith Baverstock
Interface, Royal Society Publishing, DOI: 10.1098/rsif.2013.1017Published 19 February 2014